CBL Antilichaam: Biotine (ARP35761_P050-Biotine)

Cbl proto-oncogene, E3 ubiquitin protein ligase

CBL2, NSLL, C-CBL, RNF55, FRA11B

867

P22681

NP_005179

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast

The immunogen is a synthetic peptide directed towards the following sequence NIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVL

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

ERBB4; EGFR; SIRT2; FRS3; PRPSAP2; YWHAH; YWHAE; GRB2; CAPZA1; SH3KBP1; CD2AP; UBC; NEDD8; SUMO1; EPHA2; CRK; ERBB2; NCK2; NCK1; UBE2D2; PIK3R1; LOX; YWHAB; FLT3; IRF1; MYO1C; TNS4; WAS; UBE2D3; PTEN; EPHB1; CTNNB1; CRKL; CBL; STAT5A; SRC; SHC1; RET; ITGA

Biotin

Polyclonal Antibody

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 75%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

100 kDa

Wet Ice

906

CBL

CBL

Rabbit

E3 ubiquitin-protein ligase CBL

NM_005188

NIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVL