CBS Antibody / Cystathionine Beta Synthase

In addition to its role in cysteine biosynthesis, CBS activity contributes to the regulation of homocysteine levels. Elevated homocysteine is a known risk factor for cardiovascular disease, stroke, and neurodegeneration. Mutations in the CBS gene are responsible for homocystinuria, a metabolic disorder characterized by abnormal accumulation of homocysteine, highlighting the enzyme's clinical significance. Researchers employ a CBS antibody to study enzyme expression and function in metabolic pathways and disease models. CBS is also involved in producing hydrogen sulfide (H2S), a gaseous signaling molecule with important roles in vascular function, neuromodulation, and cytoprotection. Dysregulated H2S production has been associated with cancer, hypertension, and neurological disease. Investigating CBS with a CBS antibody allows researchers to better understand its enzymatic versatility and its impact on multiple signaling networks. NSJ Bioreagents offers a high-quality CBS antibody validated for applications such as western blot, immunohistochemistry, and immunoprecipitation. Selecting a CBS antibody from NSJ Bioreagents ensures reliable detection and reproducible results in studies of sulfur metabolism, homocysteine regulation, and disease biology.

Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Flow cytometry: 1-3ug/million cells, Immunofluorescence: 5 µg/mL, ELISA: 0.1-0.5 µg/mL

P35520

Human, Mouse, Rat

A human recombinant partial protein (amino acids K102-E342) was used as the immunogen for the CBS antibody.

WB, IHC-P, FACS, IF, ELISA

Antigen affinity purified

Antigen affinity purified

Lyophilized from 1X PBS with 2% Trehalose

This CBS antibody is available for research use only.

After reconstitution, the CBS antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Optimal dilution of the CBS antibody should be determined by the researcher.

Nuclear, cytoplasmic

IHC staining of FFPE human kidney tissue with CBS antibody, HRP-secondary and DAB substrate. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.