CBS polyklonaal antilichaam

The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene.

9007-83-4

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

CBS; HIP4

P35520

Human, Mouse, Rat

Recombinant fusion protein of human CBS (NP_000062.1) .

Unconjugated

WB, IF/ICC

WB,1:500 - 1:1000|IF/ICC,1:50 - 1:200

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Unmodified

61KDa

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.

CBS polyclonal antibody detects endogenous levels of CBS protein.

Western blot analysis of CBS expression in Hela (A), MCF7 (B), Romas (C), mouse brain (D) whole cell lysates.

Rabbit