CBSR (fosfo Tyr561) Antilichaam

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development.

1436

P07333

NP_001275634.1

Human, Mouse

CSFR (phospho Tyr561) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 561 (N-S-Y (p) -T-F) derived from Human CSFR .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

130 kDa

IgG

The antibody detects endogenous levels of CSFR only when phosphorylated at tyrosine 561.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

CSF1R

Colony stimulating factor 1 receptor

Homo sapiens

Hampe A., Oncogene Res. 4:9-17 (1989) .

Andre C., Genomics 39:216-226 (1997) .

Liu T., J. Proteome Res. 4:2070-2080 (2005) .

CD115, CSF-1-R, CSFMR, FMS, M-CSFR

WB, IHC

27262659

Liquid