CCDC141 Antilichaam

CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1) -binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.

285025

Q6ZP82

NP_775919

Human, Mouse

Unconjugated

Primary Antibodies

Homeostasis

CCDC141 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

CCDC141 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CCDC141 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least four isoforms of CCDC141 are known to exist.

CCDC141

Coiled-coil domain containing 141

Homo sapiens

Fukuda T, Sugita S, Inatome R, et al. CAMDI, a novel disrupted in schizophrenia 1 (DISC1) -binding protein, is required for radial migration. J. Biol. Chem. 2010; 285:40554-61.

CCDC141 Antibody: CAMDI, Coiled-coil domain-containing protein 141

ELISA, WB, IHC-P, IF

299829223

Liquid