CCKBR-agonist- 1

CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor (CCKBR) agonist with an EC50 of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC50 of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase (ADAM10) and calcium signaling molecule PLCB4, reduce the number of amyloid β (Aβ) plaques, and promote long-term potentiation (LTP) . CCKBR agonist-1 can be used for the study of Alzheimer's disease[1].

2923120-30-1

12352209

Amyloid-β; Cholecystokinin Receptor; MMP

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Neurological Disease

O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CC(Br)=CC=C3)C(N)=O)=O)=O)=O)C

C32H39BrN6O7

699.59

[1]Wang JL, et al. Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment. Cell. 2025 Nov 20:S0092-8674 (25) 01238-3.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11540/

Peptides

No Development Reported

ADAM10; CCKBR