CCKBR-agonist-2
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimer's disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function[1].
923714-61-8
12352005
Cholecystokinin Receptor
GPCR/G Protein; Neuronal Signaling
Neurological Disease
COC1=CC(OC)=CC(C(NC2=C(C=CC=C2)O)=O)=C1
C15H15NO4
273.28
[1]Wang JL, et al. Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment. Cell. 2025 Nov 20:S0092-8674 (25) 01238-3.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-179721/
Reference compound1
No Development Reported
Beschrijving
CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has
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