CCL12 / MCP-5 eiwit (zijn label)

Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impaired fibronectin and collagen deposition and indirectly stimulated collagen degradation through upregulation of matrix metalloproteinase-2. In post-MI patients, circulating LPS levels strongly associated with the Ccl12 homologue monocyte chemotactic protein 1 (MCP-1) . Both MCP-1 and MCP-5 are HIF-1 target genes and that HIF-1alpha is involved in transcriptional induction of these two chemokines in astrocytes by hypoxia.

MCP-5 Protein; Mcp5 Protein; Scya12 Protein

NP_035461.2

Mouse

Mouse

His-Tag

See Datasheet send with the product

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> 90 % as determined by SDS-PAGE

Data not available

92

Lyophilized

PBS, pH 7.4

See Datasheet send with the product

10.7 kDa

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Yeast