CCL17 Antilichaam

CCL17 Antibody: CCL17, also known as TARC, binds to chemokine receptors CCR4 and CCR8 and plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. CCL17 is secreted from monocyte-derived DCs and endothelial cells and is responsible for selective recruitment and migration of activated Th2 lymphocytes. CCL17 is also required for CCR7 and CXCR4-dependent migration of cutaneous dendritic cells under inflammatory conditions.

6361

Q92583

NP_002978

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

CCL17 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1466 - Rat Spleen Tissue Lysate

1 mg/mL

CCL17 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CCL17 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

10 kDa

IgG

CCL17

Cat. No. 10-901 - Human Spleen Tissue Slide

Chemokine (C-C motif) ligand 17

Homo sapiens

Imai T, Baba M, Nishimura M, et al. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 1997; 272:15036-42.

Bernardini G, Hedrick J, Sozzani S, et al. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur. J. Immunol. 1998; 28:582-8.

Alferink J, Lieberam I, Reindl W, et al. Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J. Exp. Med. 2003; 197:585-99.

Stutte S, Quast T, Gerbitzki N, et al. Requirement of CCL17 for CCR7 and CXCR4-dependent migration of cutaneous dendritic cells. Proc. Natl. Acad. Sci. USA 2010; 107:8736-41.

CCL17 Antibody: TARC, ABCD-2, SCYA17, A-152E5.3, TARC, C-C motif chemokine 17, CC chemokine TARC

ELISA, WB, IHC-P, IF

4506829

Liquid