CCL4 Antilichaam

CCL4 Antibody: CCL4, also known as macrophage inflammatory protein 1-beta (MIP1B), belongs to the intercrine beta (chemokine CC) family. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ; with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells.

6351

P13236

NP_002975

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

CCL4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rabbit: (80%), Pig: (80%), Bovine: (85%)

CCL4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CCL4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 10 kDa

IgG

CCL4

Chemokine (C-C motif) ligand 4

Homo sapiens

Baixeras E, Roman-Roman S, Jitsukawa S, et al. Cloning and expression of a lymphocyte activation gene (LAG-1) . Mol. Immunol. 1990; 27:1091-102.

Maurer M and von Stebut E. Macrophage inflammatory protein-1. Int. J. Biochem. Cell Biol. 2004; 36:1882-6.

Margolis LB, Glushakova S, Grivel JC, et al. Blockade of CC chemokine receptor 5 (CCR5) -tropic human immunodeficiency virus-1 replication in human lymphoid tissue by CC chemokines. J. Clin. Invest. 1998; 101:1876-80.

CCL4 Antibody: ACT2, G-26, HC21, LAG1, LAG-1, MIP1B, SCYA2, SCYA4, MIP1B1, AT744.1, MIP-1-beta, C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein

ELISA, WB, IHC-P, IF

4506845

Liquid