CCL5 / RANTES eiwit (Zijn & mucine label)

Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokin ligand 5 (CCL5) is chemotactic for T cells, basophils and eosinophils. Chemokin ligand 5 (CCL5) has been considered a HIV-supressor secreted by CD8+ T cells and other immune cells. Chemokin ligand 5 (CCL5) is a key to activating recruit leukocytes into inflammatory sites and in the presence of particular cytokines released by T cells, it can change the NK cells into CHAK cells.

D17S136E Protein; eoCP Protein; MGC17164 Protein; RANTES Protein; SCYA5 Protein; SIS-delta Protein; SISd Protein; TCP228 Protein

NP_002976.2

Human

Human

His-/mucin-Tag

See Datasheet send with the product

< 1.0 EU per μg of the protein as determined by the LAL method

> 95 % as determined by SDS-PAGE

Data not available

318

Lyophilized

PBS, pH 7.4

See Datasheet

50 - 80 kDa (glycosylated)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells