CCM2 Mouse Monoclonal Antibody [Kloon ID: LBI1E9]

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Carrier-free (BSA/glycerol-free) CCM2 mouse monoclonal antibody, clone LBI1E9

C7orf22; OSM; PP10187

Homo sapiens CCM2 scaffold protein (CCM2), transcript variant 2, mRNA.

83605

Q9BSQ5

Unconjugated

WB 1:500~2000, IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

CCM2

https://www.ncbi.nlm.nih.gov/gene/?term=83605

https://www.uniprot.org/uniprot/Q9BSQ5