CCND1 Antilichaam - middengebied: Biotine (ARP30163 P050-Biotine)

Cyclin D1

BCL1, PRAD1, U21B31, D11S287E

595

P24385

NP_444284

Human, Rat, Cow, Dog, Horse, Pig, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human CCND1

CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

CDKN1B; CDKN1A; CDK4; RELA; FBXO31; UBC; FBXO4; CAMK1; TP73; RB1; CDK2; HSPA8; POLR1B; MCM10; ORC4; LPL; BRINP1; CDK6; RABEP1; CARD11; CUL1; RBL2; UBTF; CCND1; ATF2; CDKN2A; FBXW8; BTRC; PPP1CC; PPP1CB; PSMA6; ITLN1; MCM7; MCM6; MCM3; MCM2; ELAVL1; PCNA

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 92%; Dog: 92%; Horse: 92%; Human: 100%; Pig: 91%; Rabbit: 83%; Rat: 85%; Yeast: 83%; Zebrafish: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

34kDa

Kibel, A.S., (2008) Prostate 68 (11), 1179-1186

Wet Ice

295

CCND1

CCND1

Rabbit

G1/S-specific cyclin-D1

NM_053056

ACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI