CCR5 (fosfo Ser349) Antilichaam

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

1234;727797

P51681

NP_000570.1

Human

CCR5 (phospho Ser349) antibody was raised against a peptide sequence around phosphorylation site of Serine 349 (E-I-S (p) -V-G) derived from Human CCR5.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

40 kDa

IgG

The antibody detects endogenous levels of CCR5 only when phosphorylated at serine 349.

Western Blot: 1:500~1:1000

Homo sapiens

Martin Oppermann, J. Biol. Chem., Mar 1999; 274: 8875.

Beatrix Pollok-Kopp, J. Biol. Chem., Jan 2003; 278: 2190 - 2198.

Ramtin Rahbar, J. Virol., Jul 2006; 80: 7245 - 7259.

H Olbrich, J. Leukoc. Biol., Mar 1999; 65: 281.

C-C CKR-5, CKR5, CHEMR13, CMKBR5, CCR-5

WB

4502639

Liquid