CCR7 Antilichaam

The CCR7 protein is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation (1,2) . The chemokine (C-C motif) ligand 19 (CCL19) has been reported to be a specific ligand of this receptor (3) .

1236

P32248

NP_001829

Human

Unconjugated

Primary Antibodies

Chemokines & Cytokines

CCR7 antibody is affinity chromatography purified via peptide column.

Cat. No. 1306 - Human Spleen Tissue Lysate

1 mg/mL

CCR7 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CCR7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

CCR7 antibody is human specific. CCR7 antibody is predicted to not cross-react with other CCR proteins.

CCR7

Cat. No. 10-901 - Human Spleen Tissue Slide

Chemokine (C-C motif) receptor 7

Homo sapiens

Birkenbach M, Josefsen K, Yalamanchil R, et al. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 1993; 67:2209-20.

Forster R, Davalos-Misslitz AC, and Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 2008; 8:362-71.

Yoshida R, Imai T, Hieshima K, et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 1997; 272:13803-9.

CCR7 Antibody: BLR2, EBI1, CD197, CDw197, CMKBR7, EVI1, C-C chemokine receptor type 7, BLR2, C-C CKR-7

ELISA, WB, IHC-P, IF

4502641

Liquid