CD10 (MME) Mouse Monoclonal Antibody [Kloon ID: LBI2A6]

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) . This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) MME mouse monoclonal antibody, clone LBI2A6

CALLA; CD10; CMT2T; NEP; SCA43; SFE

Homo sapiens membrane metalloendopeptidase (MME), transcript variant 1, mRNA.

4311

P08473

Unconjugated

Alzheimer's disease, Hematopoietic cell lineage, Renin-angiotensin system

Alzheimer's disease, Hematopoietic cell lineage, Renin-angiotensin system

IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Protease, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

MME

https://www.ncbi.nlm.nih.gov/gene/?term=4311

https://www.uniprot.org/uniprot/P08473