CD107a Antilichaam [H4A3] (Biotine)

CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.

3916

P11279

P11279

Human, Rhesus Monkey, African Green Monkey, Pigtail Macaque, Sooty Mangabey

Human adherent peripheral blood cells

[H4A3]

Biotin

Primary Antibodies

Innate Immunity

Batch dependent

Supplied in PBS/NaN3

None

Blue Ice

Store vial at 2-8˚ C

IgG1

CD107a

CD107a Antibody [H4A3] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, and immunoprecipitation assays.

LAMP1

Lysosomal-associated membrane protein 1

Homo sapiens

LAMP-1, lysosome-associated membrane protein 1

IHC-Fr, Flow

Liquid