CD115 Antilichaam [AFS98]

The AFS98 monoclonal antibody specifically reacts with the mouse CD115 molecule, a 150 kDa receptor for the colony stimulating factor (CSF-1) or macrophage CFS (M-CFS), expressed by some epithelial cells, monocytes, osteoclasts, and macrophages. The colony stimulating factor-1 regulates the proliferation and the differentiation of the monocytic lineage cells. The AFS98 antibody can be used to identify myeloid lineage cells.

12978

P09581

Mouse

AFS98

Unconjugated

Primary Antibodies

Innate Immunity

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Rat IgG2a, kappa

The AFS98 monoclonal antibody specifically reacts with the mouse CD115 molecule, a 150 kDa receptor for the colony stimulating factor (CSF-1) or macrophage CFS (M-CFS), expressed by some epithelial cells, monocytes, osteoclasts, and macrophages.

Csf1r

Colony stimulating factor 1 receptor

Mus musculus

Murayama, T., Yokode, M., Kataoka, H., Imabayashi, T., Yoshida, H., Sano, H., ... Kita, T. (1999) . Intraperitoneal administration of antic-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein Edeficient mice.Circulation,99 (13), 1740-1746.

Sudo, T., Nishikawa, S., Ogawa, M., Kataoka, H., Ohno, N., Izawa, A., Hayashi, S. (1995) . Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M.Oncogene,11 (12), 2469-2476.

Yoshino, M., Yamazaki, H., Yoshida, H., Niida, S., Nishikawa, S. I., Ryoke, K., ... Hayashi, S. I. (2003) . Reduction of osteoclasts in a critical embryonic period is essential for inhibition of mouse tooth eruption.Journal of Bone and Mineral Research,18 (1), 108-116.

Fms, CD115, Csfmr, Fim-2, CSF-1R, M-CSFR, M-CSF-R, AI323359, Csf1r

Flow, Functional Assays, WB

Liquid