CD117 Antilichaam [3C1]

The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF) . Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.

16590

P05532

P05532

Mouse

Mouse IL-3-dependent bone marrow mast cells

[3C1]

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction

0.5 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG2b

CD117

CD117 Antibody [3C1] for use in flow cytometry and immunoprecipitation assays.

Kit

Mast/stem cell growth factor receptor Kit

Mus musculus

C-Kit, mast cell growth factor, stem cell factor, steel factor, SCF

ICC, Flow

Liquid