CD11a Antilichaam [M17/4]

The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein. CD11a is the integrin alpha L chain that forms with CD18 the heterodimer molecule Lymphocyte Function-associated Antigen-1 (LFA-1) . LFA-1 is expressed on all leukocytes and is involved in intercellular adhesions. The M17/4 antibody blocks many of the LFA-1 mediated cell interaction and in vivo it prolongs allograft survival, inhibits the autoimmune response, and reduces graft versus host reactions.

16408

P24063

Mouse

M17/4

Unconjugated

Primary Antibodies, Functional Antibodies

Cancer

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Rat IgG2a, kappa

The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein.

Itgal

Integrin alpha L

Mus musculus

Saban, M. R., Saban, R., Bjorling, D., Haak-Frendscho, M. (1997) . Involvement of leukotrienes, TNF-alpha, and the LFA-1/ICAM-1 interaction in substance P-induced granulocyte infiltration.Journal of leukocyte biology,61 (4), 445-451.

Zhao, Y., Iwata, M. (1995) . Cross-linking of the TCRCD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: the signal is canceled by FK506.International immunology,7 (9), 1387-1396.

Kootstra, C. J., Van Der Giezen, D. M., Van Krieken, J. H. J. M., De Heer, E., Bruijn, J. A. (1997) . Effective treatment of experimental lupus nephritis by combined administration of anti‐CD11a and anti‐CD54 antibodies.Clinical Experimental Immunology,108 (2), 324-332.

Cd11a, LFA-1, Ly-15, Ly-21, (p180), LFA-1A, Itgal

Flow, Functional Assays

Liquid