CD11b (activering epitoop) Antilichaam [CBRM1/5]

The CBRM1/5 monoclonal antibody binds with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin β2) a complex known as Mac-1. CD11b is expressed on the surface of activated lymphocytes, a subset of natural killer cells, granulocytes, and monocytes. It functions as a receptor in cell-cell and cell-matrix interactions and as a receptor for iC3b, ICAM-1, ICAM-2, and ICAM-3 intercellular adhesion molecules. The CBRM1/5 specifically reacts with the activation-specific epitope of the Mac-1 molecule, in the I domain on the alpha chain near the ligand binding site. The antibody has been reported to inhibit the cellular adhesion mediated by Mac-1.

3684

P11215

Human

CBRM1/5

Unconjugated

Primary Antibodies

Innate Immunity

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Mouse IgG1, kappa

The CBRM1/5 monoclonal antibody binds with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin β2) a complex known as Mac-1.

ITGAM

Integrin, alpha M (complement component 3 receptor 3 subunit)

Homo sapiens

Oxvig, C., Lu, C., Springer, T. A. (1999) . Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.Proceedings of the National Academy of Sciences,96 (5), 2215-2220.

Diamond, M. S., Springer, T. A. (1993) . A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.The Journal of cell biology,120 (2), 545-556.

Shimaoka, M., Shifman, J. M., Jing, H., Takagi, J., Mayo, S. L., Springer, T. A. (2000) . Computational design of an integrin I domain stabilized in the open high affinity conformation.Nature Structural Molecular Biology,7 (8), 674-678.

CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM

Flow, Functional Assays

Liquid