CD11b Antilichaam [ICRF444]

The ICRF44 monoclonal antibody specifically reacts with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin beta2) a complex known as Mac-1. CD11b is expressed on the surface of activated lymphocytes, a subset of natural killer cells, granulocytes, and monocytes. It functions as a receptor in cell-cell and cell-matrix interactions and as a receptor for iC3b, ICAM-1, ICAM-2, and ICAM-3 intercellular adhesion molecules.

3684

P11215

Human

ICRF44

Unconjugated

Primary Antibodies

Innate Immunity

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1, kappa

The ICRF44 monoclonal antibody specifically reacts with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin beta2) a complex known as Mac-1.

ITGAM

Integrin, alpha M (complement component 3 receptor 3 subunit)

Homo sapiens

Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., van der Merwe, P. A. (1997) .The leucocyte antigen factsbook. Academic Press.

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Sotiriou, S. N., Orlova, V. V., Al-Fakhri, N., Ihanus, E., Economopoulou, M., Isermann, B., ... Chavakis, T. (2006) . Lipoprotein (a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin.The FASEB journal,20 (3), 559-561.

CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM

Flow, Functional Assays, IF, IP, WB

Liquid