CD11b Antilichaam [M1/70]

CD11b, the integrin alphaM subunit, combines with CD18, the integrin beta2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.

16409

P05555

P05555

Mouse, Human, Rhesus Monkey, Baboon, Rabbit

C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes

[M1/70]

Unconjugated

Primary Antibodies

Immunology, Neuroscience, Signal Transduction

0.5 mg/mL

Supplied in PBS

None

Dry Ice

Store vial at -20˚ C

IgG2b

CD11b

CD11b Antibody [M1/70] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and blocking assays.

Itgam

Integrin alpha M

Mus musculus

Integrin alphaM, Mac-1alpha, Mac-1, Mo1, CR3, C3biR

ELISA, WB, IP, Neutralization Assay

Liquid