CD127 Antilichaam [A7R34] (APC)

The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.

16197

P16872

Mouse

A7R34

APC

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Rat IgG2a, kappa

The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels.

Il7r

Interleukin 7 receptor

Mus musculus

Vudattu, N. K., Magalhaes, I., Schmidt, M., Seyfert-Margolis, V., Maeurer, M. J. (2007) . Reduced numbers of IL-7 receptor (CD127) expressing immune cells and IL-7-signaling defects in peripheral blood from patients with breast cancer. International journal of cancer,121 (7), 1512-1519.

Pandrau-Garcia, D., de Saint-Vis, B., Saeland, S., Renard, N., Ho, S., Moreau, I., ... Galizzi, J. P. (1994) . Growth inhibitory and agonistic signals of interleukin-7 (IL-7) can be mediated through the CDw127 IL-7 receptor.Blood,83 (12), 3613-3619.

Van Roon, J. A., Hartgring, S. A., van der Wurff-Jacobs, K. M., Bijlsma, J. W., Lafeber, F. P. (2010) . Numbers of CD25+ Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients.Rheumatology,49 (11), 2084-2089.

CD127, IL-7Ralpha, Il7r

Flow

Liquid