CD13 (ANPEP) Mouse Monoclonal Antibody [Kloon ID: UMLBI275]

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) CD13 mouse monoclonal antibody, clone UMLBI275

APN; CD13; GP150; LAP1; P150; PEPN

Homo sapiens alanyl aminopeptidase, membrane (ANPEP), transcript variant 1, mRNA.

290

P15144

Unconjugated

Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system

Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system

IHC 1:1000

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, ES Cell Differentiation/IPS, Protease, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

ANPEP

https://www.ncbi.nlm.nih.gov/gene/?term=290

https://www.uniprot.org/uniprot/P15144