CD138 Antilichaam [DL-101] (PE)

The DL-101 monoclonal antibody specifically reacts with human CD138, a 85-92 kDA type I heparan sulfate proteoglycan. CD138 is known as Syndecan-1 and is expressed on pre-B cells, immature B cells, plasma cells, and malignant plasma cells, to the exclusion of mature circulating B cells. Syndecan-1 is also expressed on vascular smooth muscle, endothelial, neural, and embryonic mesenchymal cells. It is involved in cellular proliferation, cellular migration, and acts as an extracellular matrix receptor. Among the hematopoietic elements, CD138 is a useful marker for plasma cells.

6382

P18827

Human

DL-101

PE

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1, kappa

The DL-101 monoclonal antibody specifically reacts with human CD138, a 85-92 kDA type I heparan sulfate proteoglycan.

SDC1

Syndecan 1

Homo sapiens

Kayagaki, N., Kawasaki, A., Ebata, T., Ohmoto, H., Ikeda, S., Inoue, S., ... Yagita, H. (1995) . Metalloproteinase-mediated release of human Fas ligand.The Journal of experimental medicine,182 (6), 1777-1783.

Oyaizu, N., Adachi, Y., Hashimoto, F., McCloskey, T. W., Hosaka, N., Kayagaki, N., ... Pahwa, S. (1997) . Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection.The Journal of Immunology,158 (5), 2456-2463.

Villunger, A., Egle, A., Marschitz, I., Kos, M., Bck, G., Ludwig, H., ... Greil, R. (1997) . Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.Blood,90 (1), 12-20.

SDC, CD138, SYND1, syndecan, SDC1

Flow

Liquid