CD14 Antilichaam (Sup2-8] (FITC)

The Sa2-8 monoclonal antibody specifically reacts with mouse CD14, a cell surface anchored glycoprotein that is primarily expressed on macrophages and is secreted in certain conditions. CD14 associates with LPS and LBP to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The Sa2-8 antibody exhibits a weak antagonistic activate in relation to TNF alpha production and NF-kappa B activation.

929

P08571

Mouse

Sa2-8

FITC

Primary Antibodies

Innate Immunity

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Rat IgG2a, kappa

The Sa2-8 monoclonal antibody specifically reacts with mouse CD14, a cell surface anchored glycoprotein that is primarily expressed on macrophages and is secreted in certain conditions.

CD14

CD14 molecule

Homo sapiens

Akashi, S., Saitoh, S. I., Wakabayashi, Y., Kikuchi, T., Takamura, N., Nagai, Y., ... Miyake, K. (2003) . Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2 Higher Affinity than That with MD-2 or CD14.The Journal of experimental medicine,198 (7), 1035-1042.

Oliva, C., Turnbough, C. L., Kearney, J. F. (2009) . CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages.Proceedings of the National Academy of Sciences,106 (33), 13957-13962.

CD14, CD14

Flow

Liquid