CD144 Antilichaam (16B1] (PE)

The 16B1 monoclonal antibody specifically reacts with human CD144, the 140 kDA molecule called vascular endothelial (VE-cadherin) or cadherin 5. CD144 is an endothelial specific calcium-dependent adhesion molecule involved in cell contact-dependent growth inhibition, migration, survival, adhesion. It is concentrated at the intercellular boundaries of endothelial cells and essential in maintaining cell layer integrity.

1003

P33151

Human

16B1

PE

Primary Antibodies

Cancer

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1

The 16B1 monoclonal antibody specifically reacts with human CD144, the 140 kDA molecule called vascular endothelial (VE-cadherin) or cadherin 5.

CDH5

Cadherin 5, type 2 (vascular endothelium)

Homo sapiens

Corada, M., Mariotti, M., Thurston, G., Smith, K., Kunkel, R., Brockhaus, M., ... Dejana, E. (1999) . Vascular endothelialcadherin is an important determinant of microvascular integrity in vivo.Proceedings of the National Academy of Sciences,96 (17), 9815-9820.

Crosby, C. V., Fleming, P. A., Argraves, W. S., Corada, M., Zanetta, L., Dejana, E., Drake, C. J. (2005) . VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly.Blood,105 (7), 2771-2776.

May, C., Doody, J. F., Abdullah, R., Balderes, P., Xu, X., Chen, C. P., ... Bohlen, P. (2005) . Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature.Blood,105 (11), 4337-4344.

7B4, CD144, CDH5

Flow

Liquid