CD152 Antilichaam (9H10]

CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2.

12477

P09793

P09793

Mouse

Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein

[9H10]

Unconjugated

Primary Antibodies

Immunology

0.5 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG

CD152

CD152 Antibody [9H10] for use in flow cytometry, ELISA, blocking, and costimulation assays.

Ctla4

Cytotoxic T-lymphocyte-associated protein 4

Mus musculus

CTLA-4, cytotoxic T-lymphocyte protein 4

IHC-Fr, ICC, Flow, Separation

Liquid