CD152 Antilichaam [BNI3]

The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) . CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86) . The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.

1493

P16410

Human

BNI3

Unconjugated

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Mouse IgG2a, kappa

The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) .

CTLA4

Cytotoxic T-lymphocyte-associated protein 4

Homo sapiens

Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., van der Merwe, P. A. (1997) .The leucocyte antigen factsbook. Academic Press.

Lindsten, T., Lee, K. P., Harris, E. S., Petryniak, B., Craighead, N., Reynolds, P. J., ... Gray, G. S. (1993) . Characterization of CTLA-4 structure and expression on human T cells.The Journal of Immunology,151 (7), 3489-3499.

Kuiper, H. M., Brouwer, M., Linsley, P. S., Van Lier, R. A. (1995) . Activated T cells can induce high levels of CTLA-4 expression on B cells.The Journal of Immunology,155 (4), 1776-1783.

CD, GSE, GRD4, ALPS5, CD152, CTLA-4, IDDM12, CELIAC3, CTLA4

Flow

Liquid