CD152 Antilichaam [UC10-4F10-11] (APC)

The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.

12477

P09793

Mouse

UC10-4F10-11

APC

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Armenian Hamster IgG

The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152.

Ctla4

Cytotoxic T-lymphocyte-associated protein 4

Mus musculus

Herling, M., Teitell, M. A., Shen, R. R., Medeiros, L. J., Jones, D. (2003) . TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin.Blood,101 (12), 5007-5009.

Peduzzi, E., Groeper, C., Schtte, D., Zajac, P., Rondini, S., Mensah-Quainoo, E., ... Daubenberger, C. A. (2007) . Local activation of the innate immune system in Buruli ulcer lesions.Journal of Investigative Dermatology,127 (3), 638-645.

Sun, Q., Woodcock, J. M., Rapoport, A., Stomski, F. C., Korpelainen, E. I., Bagley, C. J., ... Lopez, A. F. (1996) . Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist.Blood,87 (1), 83-92.

Cd152, Ly-56, Ctla-4, Ctla4

Flow

Liquid