CD154 Antilichaam [MR1]

CD154, formerly known as CD40 ligand and gp39, is a type II integral membrane protein and a member of the tumor necrosis factor (TNF) family of ligands. It is an important accessory molecule in T cell-B cell costimulatory interactions and is expressed predominantly on activated CD4+ T lymphocytes. It is also present on the surface of activated Th0, Th1, and Th2 T cell clones. Its expression is transient and cyclosporin-sensitive. The MR1 monoclonal antibody binds to murine CD154 with high affinity, blocks binding to CD40, and blocks CD154 function. Administration of this antibody to mice blocks the ability to mount primary and secondary immune responses to TD antigens yet does not alter the immune response to TI antigens.

21947

P27548

P27548

Mouse

Activated mouse Th1 clone D1.6

[MR1]

Unconjugated

Primary Antibodies

Immunology

0.5 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG

CD154

CD154 Antibody [MR1] for use in flow cytometry, immunohistochemistry, immunoprecipitation, ELISA, and blocking assays.

Cd40lg

CD40 ligand

Mus musculus

CD40L, CD40 ligand, gp39

Flow

Liquid