CD154 Antilichaam (MR1] (PE)

The MR1 monoclonal antibody specifically reacts with mouse CD154, a 39kDA transmembrane glycoprotein also known as CD40 ligand and gp39. CD154 is expressed on activated T cells and plays a role in B-T cell costimulation. The interaction of CD154 with CD40 induces B cell cycle entry and the signaling for T-dependent B cell activation. By interfering with this interaction, the MR1 antibody is reported to inhibit T and B lymphocyte activation.

21947

P27548

Mouse

MR1

PE

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Armenian Hamster IgG

The MR1 monoclonal antibody specifically reacts with mouse CD154, a 39kDA transmembrane glycoprotein also known as CD40 ligand and gp39.

Cd40lg

CD40 ligand

Mus musculus

Frster, R., Kremmer, E., Schubel, A., Breitfeld, D., Kleinschmidt, A., Nerl, C., ... Lipp, M. (1998) . Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation.The Journal of Immunology,160 (3), 1522-1531.

Schabath, R., M, G., Schubel, A., Kremmer, E., Lipp, M., Frster, R. (1999) . The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation.Journal of leukocyte biology,66 (6), 996-1004.

Gupta, S. K., Lysko, P. G., Pillarisetti, K., Ohlstein, E., Stadel, J. M. (1998) . Chemokine Receptors in Human Endothelial Cells FUNCTIONAL EXPRESSION OF CXCR4 AND ITS TRANSCRIPTIONAL REGULATION BY INFLAMMATORY CYTOKINES.Journal of Biological Chemistry,273 (7), 4282-4287.

IGM, IMD3, Ly62, TRAP, gp39, CD154, Cd40l, HIGM1, Ly-62, T-BAM, CD40-L, Tnfsf5, Cd40lg

Flow

Liquid