CD16 Antilichaam [2,4G2] (FITC)

The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc gamma III) and CD 32 (Fc gamma II) . CD16 and CD32 are low affinity receptors for the IgG Fc domain and are expressed by B lymphocytes, NK cells, kupffer cells, mast cells, monocytes, macrophages, granulocytes, immature thymocytes, neutrophils, and some activated mature T cells.The 2.4G2 antibody blocks the binding of immunoglobulins to CD16 and CD32, and possibly to Fc gamma I receptor.

14131

P08508

Mouse

2.4G2

FITC

Primary Antibodies

Innate Immunity

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Rat IgG2b

The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc gamma III) and CD 32 (Fc gamma II) .

Fcgr3

Fc receptor, IgG, low affinity III

Mus musculus

Choi, E. I., Wang, R., Peterson, L., Letvin, N. L., Reimann, K. A. (2008) . Use of an anti‐CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques.Immunology,124 (2), 215-222.

Perussia, B. I. C. E., Trinchieri, G. I. O. R. G. I. O. (1984) . Antibody 3G8, specific for the human neutrophil Fc receptor, reacts with natural killer cells.The Journal of Immunology,132 (3), 1410-1415.

Vossebeld, P. J., Homburg, C. H., Roos, D., Verhoeven, A. J. (1997) . The anti-Fc-gamma RIII mAb 3G8 induces neutrophil activation via a cooperative action of Fc-gamma RIIIb and Fc-gamma RIIa.The international journal of biochemistry cell biology,29 (3), 465-473.

Fcgr3, Fcgr3

Flow

Liquid