CD16 Antilichaam [CB16]

The CB15 monoclonal antibody specifically binds to human CD16, a low affinity Fc receptor. It is expressed on NK, neutrophils, macrophages, monocytes, and placental trophoblasts. CD16 is expressed in CD16a and CD16b forms. CD16a is a polyeptide anchored transmembrane protein and CD16b is a monomeric glycosylphosphatidylinositol (GPI) -anchored protein found in neutrophils. CD16 is reported to be involved in NK cell activation and signal transduction.

2214

P08637

Human

CB16

Unconjugated

Primary Antibodies

Innate Immunity

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Mouse IgG1

The CB15 monoclonal antibody specifically binds to human CD16, a low affinity Fc receptor.

FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Homo sapiens

Deaglio, S., Zubiaur, M., Gregorini, A., Bottarel, F., Ausiello, C. M., Dianzani, U., ... Malavasi, F. (2002) . Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells.Blood,99 (7), 2490-2498.

Peruzzi, G., Femnou, L., Gil-Krzewska, A., Borrego, F., Weck, J., Krzewski, K., Coligan, J. E. (2013) . Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells.The Journal of Immunology,191 (4), 1883-1894.

Wirthmueller, U., Kurosaki, T., Murakami, M. S., Ravetch, J. V. (1992) . Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain.The Journal of experimental medicine,175 (5), 1381-1390.

CD16, FCG3, CD16A, FCGR3, IGFR3, IMD20, FCR-10, FCRIII, FCGRIII, FCRIIIA, FCGR3A

Flow, Functional Assays

Liquid