CD160 Antilichaam

CD160, also known as BY55, is a lipid-anchored cell membrane glycoprotein that contains one immunoglobulin-like domain (1) . It is expressed in small intestine, spleen and functional NK and T cytotoxic lymphocytes (1,2) . CD160 exists as a disulfide-linked homomultimer that functions as a receptor for MHC (major histocompatability complex) molecules and is thought to regulate the function of NK cells (2,3) . Additionally, CD160 interacts with TNFRSF14 and, via this interaction, is able to negatively regulate CD4+ T cell activation, indicating a role in immune system regulation (4) .

11126

O95971

NP_008984

Human, Mouse

Unconjugated

Primary Antibodies

Immunology

CD160 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

CD160 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CD160 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

CD160 antibody is human and mouse reactive. Multiple isoforms of CD160 are known to exist.

CD160

CD160 molecule

Homo sapiens

Anumanthan A, Bensussan A, Boumsell L, et al. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J. Immunol. 1998; 161:2780-90.

Agrawal S, Marquet J, Freeman GJ, et al. Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. J. Immunol. 1999; 162:1223-6.

Le Bouteiller P, Tabiasco J, Polgar B, et al. CD160: a unique activating NK cell receptor. Immunol. Lett. 2011;138:93-6

Chabot S, Jabrane-Ferrat N, Bigot K, et al. A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor. J. Exp. Med. 2011; 208:973-86.

CD160 Antibody : NK1, BY55, NK28, CD160 antigen, Natural killer cell receptor BY55

ELISA, WB, IF

5901910

Liquid