CD16/CD32 Recombinant antilichaam [2,4G2] (OAAV00085)

Fc receptor, IgG, low affinity IIb

AI528646; CD32; F630109E10Rik; fc gamma receptor IIB; Fc gamma RIIB; Fc[g]; Fc[g]RII; Fcg; Fcgamm; fc-gamma RII; Fc-gamma RIII; Fc-gamma-RII; fc-gamma-RIIB; FcgammaRIIB; Fcgr; Fcgr2; Fcgr2a; FcgRII; Fcr-; Fcr-2; Fcr-3; fcRII; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma Fc region receptor II-b; Ly-1; Ly-17; LyM-; LyM-1; Ly-m2; Ly-m20; lymphocyte antigen 17.

14130

P08101|P08508

Mouse

Mouse BALB/c Macrophage J774 Cell Line.

2.4G2

Recombinant Monoclonal Antibody

Purified

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor which binds to IgG1, IgG2a and IgG2b (PubMed:17558411) . Mediates neutrophil activation by IgG complexes redundantly with Fcgr4 (PubMed:18097064) .|Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively.

PBS with 0.02% Proclin 300.

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

IgG2b, kappa

This antibody binds to an epitope on the extracellular domains of the mouse FcγIII and FcγII, thereby inhibiting their ability to bind antibodies via their Fc region._x005F _x005F receptors. Also binding the FcγI receptor (CD64) via its Fc domain.

Fcgr2b

Rat

Low affinity immunoglobulin gamma Fc region receptor II|Low affinity immunoglobulin gamma Fc region receptor III

Fcgr2b