CD178 Antilichaam [NoK-1]

The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand. CD178 is a TNF superfamily type II transmembrane glycoprotein expressed by activated T and NK cells and is involved in Fas-mediated apoptosis of lymphocytes. CD178 is also expressed by monocytes, neutrophils, granulocytes and the parenchymal cells of the retina and cornea. The NOK-1 antibody has been reported to bind to COOH-terminus of the Fas ligand in the region associated with Fas binding.

356

P48023

Human

NOK-1

Unconjugated

Primary Antibodies, Functional Antibodies

Apoptosis

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Mouse IgG1, kappa

The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand.

FASLG

Fas ligand (TNF superfamily, member 6)

Homo sapiens

Kayagaki, N., Kawasaki, A., Ebata, T., Ohmoto, H., Ikeda, S., Inoue, S., ... Yagita, H. (1995) . Metalloproteinase-mediated release of human Fas ligand.The Journal of experimental medicine,182 (6), 1777-1783.

Oyaizu, N., Adachi, Y., Hashimoto, F., McCloskey, T. W., Hosaka, N., Kayagaki, N., ... Pahwa, S. (1997) . Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection.The Journal of Immunology,158 (5), 2456-2463.

Villunger, A., Egle, A., Marschitz, I., Kos, M., Bck, G., Ludwig, H., ... Greil, R. (1997) . Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.Blood,90 (1), 12-20.

APTL, FASL, CD178, CD95L, ALPS1B, CD95-L, TNFSF6, APT1LG1, FASLG

Flow, Functional Assays

Liquid