CD178 Antilichaam [NoK-1] (APC)

The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand. CD178 is a TNF superfamily type II transmembrane glycoprotein expressed by activated T and NK cells and is involved in Fas-mediated apoptosis of lymphocytes. CD178 is also expressed by monocytes, neutrophils, granulocytes and the parenchymal cells of the retina and cornea. The NOK-1 antibody has been reported to bind to COOH-terminus of the Fas ligand in the region associated with Fas binding.

356

P48023

Human

NOK-1

APC

Primary Antibodies

Apoptosis, Cancer

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1, kappa

The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand.

FASLG

Fas ligand (TNF superfamily, member 6)

Homo sapiens

Stber, E., Neurath, M., Calderhead, D., Perry Fell, H., Strober, W. (1995) . Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells.Immunity,2 (5), 507-521.

Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., ... Okumura, K. (1999) . CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.The Journal of Immunology,162 (12), 7058-7066.

Calderhead, D. M., Buhlmann, J. E., Van den Eertwegh, A. J., Claassen, E., Noelle, R. J., Fell, H. P. (1993) . Cloning of mouse Ox40: a T cell activation marker that may mediate TB cell interactions.The Journal of Immunology,151 (10), 5261-5271.

APTL, FASL, CD178, CD95L, ALPS1B, CD95-L, TNFSF6, APT1LG1, FASLG

Flow

Liquid