CD19 Antilichaam [HIB19] (APC)

The HIB19 monoclonal antibody reacts with a human 95 kDa transmembrane glycoprotein known as CD19, which is expressed by B lymphocytes during all the developmental stages, except for the terminally differentiated plasma cells. CD19 is also expressed on follicular dendritic cells, and seems to ensure the regulation of B lymphocytes proliferation. CD19, CD21, CD81, MHC class II, and Leu13 can bind together and form a complex which associates with the B cell receptor (BCR) on the surface of B lymphocytes and facilitates the signal transduction.

930

P15391

Human

HIB19

APC

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1, kappa

The HIB19 monoclonal antibody reacts with a human 95 kDa transmembrane glycoprotein known as CD19, which is expressed by B lymphocytes during all the developmental stages, except for the terminally differentiated plasma cells.

CD19

CD19 molecule

Homo sapiens

Cherukuri, A., Cheng, P. C., Pierce, S. K. (2001) . The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens.The Journal of Immunology, 167 (1), 163-172.

Krop, I., De Fougerolles, A. R., Hardy, R. R., Allison, M., Schlissel, M. S., Fearon, D. T. (1996) . Self-renewal of B-1 lymphocytes is dependent on CD19.European journal of immunology,26 (1), 238-242.

Engel, P., Zhou, L. J., Ord, D. C., Sato, S., Koller, B., Tedder, T. F. (1995) . Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.Immunity,3 (1), 39-50.

Sato, S., Jansen, P. J., Tedder, T. F. (1997) . CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.Proceedings of the National Academy of Sciences,94 (24), 13158-13162.

B4, CVID3, CD19

Flow

Liquid