CD2 Antilichaam [RPA-2.10]

The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein. CD2 is expressed on NK cells, thymocytes, T lymphocytes, and B cell subsets. CD2 is involved in cell-cell adhesion, T cell activation, and T cell signaling. Its ligand is CD58 and it is reported to bind to CD48, CD59, and CD15. The RPA-2.10 antibody is reported to be cross-reactive with pigs and non-human primates..

914

P06729

Human

RPA-2.10

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Mouse IgG1, kappa

The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein.

CD2

CD2 molecule

Homo sapiens

Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Hahn, W. C., Burakoff, S. J., Bierer, B. E. (1993) . Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58.The Journal of Immunology,150 (7), 2607-2619.

Aversa, G. G., Bishop, G. A., Suranyi, M. G., Hall, B. M. (1987, February) . RPA-2.10: an anti-CD2 monoclonal antibody that inhibits alloimmune responses and monitors T cell activation. InTransplantation proceedings (Vol. 19, No. 1 Pt 1, pp. 277-278) .

T11, SRBC, LFA-2, CD2

Flow, Functional Assays

Liquid