CD22-antilichaam [2D6] (PE-Cy5)

CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.

12483

P35329

P35329

Mouse

Splenic lymphocyte plasma membranes from CBA x C57 F1 mice

[2D6]

PE-Cy5

Primary Antibodies

Cancer, Stem Cell, Immunology

0.1 mg/mL

Supplied in PBS/NaN3 and a stabilizing agent

None

Blue Ice

Store vial at 2-8˚ C

IgG1

CD22

CD22 Antibody [2D6] for use in flow cytometry assays.

Cd22

CD22 antigen

Mus musculus

Lyb-8, Leu-14, BL-CAM

Flow

Liquid