CD22 Antilichaam - N-terminaal gebied: Biotine (ARP59863 P050-Biotine)

CD22 molecule

SIGLEC2, SIGLEC-2

933

P20273

NP_001762

Human

The immunogen is a synthetic peptide directed towards the N terminal region of human CD22

CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins; one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

UBC; CD19; INPP5D; LCP2; AP2M1; SHC1; SYK; PTPN6; PLCG1; PIK3R1; LYN; PTPRC; IGHM; HP; ST6GAL1; ATP2B4; GRB2; AP2A1

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

95kDa

Wet Ice

847

CD22

CD22

Rabbit

B-cell receptor CD22

NM_001771

TYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQF