CD23 Antilichaam [2G8]

The CD23 antigen is the low affinity IgE Fc receptor, which is a 45-49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells) and can also be found on the surface of T cells, macrophages and platelets. It is distinct from the high affinity IgE receptors found on basophils and mast cells which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a “membrane bound cytokine, " in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

14128

P20693

P20693

Mouse

FcepsilonR isolated from B cell lymphoma cell line M12.4.5

[2G8]

Unconjugated

Primary Antibodies

Immunology, Stem Cell, Cancer, Cell Cycle

0.5 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG2a

CD23

CD23 Antibody [2G8] for use in flow cytometry, ELISA, and immunohistochemistry assays.

Fcer2a

Fc receptor, IgE, low affinity II, alpha polypeptide

Mus musculus

FcepsilonRII, BLAST-2, low affinity IgE receptor, Ly-42

Flow, IP, Costimulation

Liquid