CD24 , Cynomolgus (HEK293, His)

CD24 protein plays a pivotal role in cell differentiation across various cell types, with signaling potentially initiated by lectin-like ligand binding to CD24 carbohydrates, transduced through second messengers released from the GPI-anchor. CD24 also modulates B-cell activation responses, promoting AG-dependent B-cell proliferation and preventing terminal differentiation into antibody-forming cells. In association with SIGLEC10, CD24 contributes to the selective suppression of the immune response to DAMPs such as HMGB1, HSP70, and HSP90, suggesting a role in immune regulation. Additionally, CD24 is implicated in controlling autoimmunity, exhibiting cell-type-specific interactions with LYN and FGR in diverse cellular processes and immune regulation. CD24 Protein, Cynomolgus (HEK293, His) is the recombinant others-derived CD24 protein, expressed by HEK293, with C-His labeled tag.

CD24 Protein, Cynomolgus (HEK293, His), Others, HEK293

12352202

/ (Gene_ID) I7GKK1 (T27-K54) (Accession)

Approximately 25-35 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

[1]Suzuki T, et al. CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system. J Immunol. 2001 May 1;166 (9) :5567-77.|[2]Jellusova J, et al. CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity. J Immunol. 2010 Apr 1;184 (7) :3618-27.|[3]Chen GY, et al. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science. 2009 Mar 27;323 (5922) :1722-5.

Room temperature in continental US; may vary elsewhere.

Recombinant Proteins