CD243 Antilichaam (UIC2] (PE)

The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp) . It is an ATP binding cassette (ABC) transport and is expressed on B, T, NK cells to the exclusion of monocytes. CD243 is involved in the process that transports molecules across the cellular membranes and plays a role in multidrug resistance. The UIC2 antibody inhibits CD243 mediated efflux.

5243

P08183

Human

UIC2

PE

Primary Antibodies

Stem Cell

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG2a

The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp) .

ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Homo sapiens

Matsumoto, M., Kikkawa, S., Kohase, M., Miyake, K., Seya, T. (2002) . Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.Biochemical and biophysical research communications,293 (5), 1364-1369.

Schreiner, B., Voss, J., Wischhusen, J., Dombrowski, Y., Steinle, A., Lochm, H., ... Wiendl, H. (2006) . Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands.The FASEB journal,20 (1), 118-120.

Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., Seya, T. (2003) . TICAM-1, an adaptor molecule that participates in Toll-like receptor 3mediated interferon--beta- induction.Nature immunology,4 (2), 161-167.

CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170, ABCB1

Flow

Liquid