CD25 Antilichaam [PC61.5]

The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor alpha chain (IL-2R alpha), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor beta) and CD 132 (IL-2 Receptor gammac, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Ralpha. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation.The PC61.5 antibody block the binding of IL-2 to both high-affinity and low-affinity receptors.

16184

P01590

Mouse

PC61.5

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Batch dependent

Phosphate-buffered aqueous solution, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C . Do not freeze.

Rat IgG1, lambda

The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor alpha chain (IL-2R alpha), expressed on early progenitors of T and B lineage, and on B and T cells.

Il2ra

Interleukin 2 receptor, alpha chain

Mus musculus

Hayashi, T., Hasegawa, K., Adachi, C. (2005) . Elimination of CD4+ CD25+ T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZBx NZW F1 mice. International journal of experimental pathology,86 (5), 289-296.

Lowenthal, J. W., Tougne, C., MacDonald, H. R., Smith, K. A., Nabholz, M. (1985) . Antigenic stimulation regulates the expression of IL 2 receptors in a cytolytic T lymphocyte clone.The Journal of Immunology,134 (2), 931-939.

Huang, B., Zhao, J., Shen, S., Li, H., He, K. L., Shen, G. X., ... Feng, Z. H. (2007) . Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling.Cancer Research,67 (9), 4346-4352.

CD25, Il2r, Ly-43, Il2ra

Flow, Functional Assays, IHC, IP

Liquid