CD252 Antilichaam [RM134L] (Biotine)

The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells. On activated B cells it enhances immunoglobulin secretion and cell proliferation. CD252 is also known as the OX-40 ligand and interacts with the OX-40 antigen found on the surface of activated T cells. The RML134L is reported to block the costimulatory activity of OX-40L.

22164

P43488

Mouse

RM134L

Biotin

Primary Antibodies

Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted biotin was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Rat IgG2b, kappa

The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells.

Tnfsf4

Tumor necrosis factor (ligand) superfamily, member 4

Mus musculus

Stber, E., Neurath, M., Calderhead, D., Perry Fell, H., Strober, W. (1995) . Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells.Immunity,2 (5), 507-521.

Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., ... Okumura, K. (1999) . CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.The Journal of Immunology,162 (12), 7058-7066.

Calderhead, D. M., Buhlmann, J. E., Van den Eertwegh, A. J., Claassen, E., Noelle, R. J., Fell, H. P. (1993) . Cloning of mouse Ox40: a T cell activation marker that may mediate TB cell interactions.The Journal of Immunology,151 (10), 5261-5271.

Ath1, gp34, Ath-1, Ox40l, TXGP1, CD134L, OX-40L, Txgp1l, Tnfsf4

Flow

Liquid