CD27 Antilichaam [O323] (APC-Cy7)

The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells. CD27 is upregulated by T lymphocytes stimulation, and binds to CD70, enhancing the interaction between T and B lymphocytes. CD27 is a marker of memory B cells.

939

P26842

Human

O323

APC-Cy7

Primary Antibodies

Immunology, Apoptosis

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Mouse IgG1, kappa

The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells.

CD27

CD27 molecule

Homo sapiens

Hendriks, J., Xiao, Y., Borst, J. (2003) . CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.The Journal of experimental medicine,198 (9), 1369-1380.

Sakanishi, T., Yagita, H. (2010) . Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice.Biochemical and biophysical research communications,393 (4), 829-835.

Gravestein, L. A., Nieland, J. D., Kruisbeek, A. M., Borst, J. (1995) . Novel mAbs reveal potent co-stimulatory activity of murine CD27.International immunology,7 (4), 551-557.

T14, S152, Tp55, TNFRSF7, S152. LPFS2, CD27

Flow

Liquid