CD27 / TNFRSF7 Proteïne (His & hFc Tag)

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

Cd27 Protein; S152 Protein; Tnfrsf7 Protein; Tp55 Protein

NP_001028298.1

Mouse

Mouse

His-/hFc-Tag

See Datasheet send with the product

< 1.0 EU per μg of the protein as determined by the LAL method

> 94 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA . Immobilized recombinant mouse CD27 at 2 μg/mL (100 μl/well) can bind biotinylated human CD70 with a linear range of 0.39-12.5 ng/mL.

410

Lyophilized

PBS, pH 7.4

See Datasheet

60 kDa (glycosylated monomer)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells